Plants get on PAR with poly( ADP ‐ribosyl)ation
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چکیده
منابع مشابه
Inhibiting poly(ADP-ribosylation) improves axon regeneration
The ability of a neuron to regenerate its axon after injury depends in part on its intrinsic regenerative potential. Here, we identify novel intrinsic regulators of axon regeneration: poly(ADP-ribose) glycohodrolases (PARGs) and poly(ADP-ribose) polymerases (PARPs). PARGs, which remove poly(ADP-ribose) from proteins, act in injured C. elegans GABA motor neurons to enhance axon regeneration. PAR...
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Poly(ADP-ribosylation) is a post-translational modification of nuclear proteins typical of most eukaryotic cells. This process participates in DNA replication and repair and is mainly regulated by two enzymes, poly(ADP-ribose) polymerase, which is responsible for the synthesis of polymers of ADP-ribose, and poly(ADP-ribose) glycohydrolase, which performs polymer degradation. The aim of this wor...
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Poly-ADP-ribosylation is a post-translational modification generated in high amounts by poly-ADP-ribose polymerases (PARPs) in response to cellular stress, especially genotoxic stimuli. DNA damage-induced PARylation significantly changes local chromatin structure and triggers the accumulation of several DNA damage response (DDR) proteins at the DNA lesions. In this review, we will discuss the r...
متن کاملPoly(ADP-ribosyl)ation in plants.
Poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribose) glycohydrolases (PARGs) are the main enzymes responsible for the post-translational modification known as poly(ADP-ribosyl)ation. These enzymes play important roles in genotoxic stress tolerance and DNA repair, programmed cell death, transcription, and cell cycle control in animals. Similar impacts are being discovered in plants, as well...
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Ribosylation and Poly(ADP-ribose) Polymerases Keun Woo Ryu,†,‡,§,∥ Dae-Seok Kim,†,‡,∥ and W. Lee Kraus*,†,‡ †Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, ‡Division of Basic Research, Department of Obstetrics and Gynecology, and Graduate School of Biomedical Sciences, Program in Genetics and Development, University of Texas Southwe...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2016
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201643453